ASSOCIATION BETWEEN ABDOMINAL OBESITY, C-PEPTIDE LEVELS, AND INSULIN RESISTANCE IN YOUNG ADULTS

Abstract

Currently, considerable attention is being paid to the concept that abdominal obesity (AO) induces a chronic low-grade systemic inflammatory response, which develops as a result of increased insulin resistance and enhanced production of inflammatory mediators due to the expansion of the adipocyte pool [1, 2]. Visceral adipose tissue is considered a key link between the development of metabolic disturbances and cardiovascular pathology. Given the high global prevalence of AO, including among young individuals [3], this factor has become one of the leading contributors to the development of comorbid conditions. A number of studies have demonstrated that adipokine imbalance is strongly associated with an increased risk of cardiometabolic diseases and their complications [4–6]. In our previous studies, we demonstrated associations between circulating adipokine levels and coronary artery disease (CAD) [7], arterial hypertension (AH) [7], as well as hypercholesterolemia. However, the contribution of adipokines to the development of comorbid conditions remains insufficiently understood. In light of the above, the aim of the present study was to investigate the characteristics of the circulating adipokine profile in young adults with comorbid pathology.