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Vol. 12 No. 12 (2025)
International Multidisciplinary Journal for Research & Development

Articles

EFFECTS OF GLIFLOZIN THERAPY ON CARDIAC STRUCTURAL CHANGES

Published 2025-12-17

  • Yusupova N.A.

Yusupova N.A.
Andijan State Medical Institute

Abstract

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Keywords

SGLT2 inhibitors, heart failure, cardiac remodeling, left atrium, left ventricular function

PDF

References

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  2. Verma S, McMurray JJ. Sodium-Glucose Cotransporter 2 Inhibitors and Cardiac Remodeling. J Am Coll Cardiol. 2018;71(15):1693–1704. doi:10.1016/j.jacc.2018.02.059.
  3. Santos-Gallego CG, et al. Impact of gliflozins on cardiac remodeling in patients with T2DM and reduced ejection fraction: the GLISCAR study. Diabetes Obes Metab. 2023;25(5):1245–1255. doi:10.1111/dom.14915.
  4. Lee MMY, et al. Effect of SGLT2 inhibitors on cardiac structure and function assessed by cardiac magnetic resonance: A systematic review and meta-analysis. ESC Heart Fail. 2023;10:3001–3015. doi:10.1002/ehf2.14492.
  5. Wiviott SD, et al. Effects of canagliflozin on cardiac remodeling and hemodynamic parameters. Sci Rep. 2023;13:48716. doi:10.1038/s41598-023-48716-y.
  6. Boudina S, et al. SGLT2 inhibitors and cardiac remodelling: RCT cardiac MRI meta-analysis. JACC Cardiovasc Imaging. 2021;14(12):2444–2455. doi:10.1016/j.jcmg.2021.06.016.
  7. Docherty KF, et al. Effects of SGLT2 inhibitors on cardiac structure and function. Heart. 2022;108:167–176. doi:10.1136/heartjnl-2021-319500.
  8. Wang Y, et al. Cardiac Fibrosis: Mechanistic Discoveries Linked to SGLT2 Inhibitors. Pharmaceutics. 2023;18(3):313. doi:10.3390/pharmaceutics18030313.

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