THE ROLE OF INTERLEUKIN-10 AND TUMOR NECROSIS FACTOR-ALPHA IN CHRONIC RHEUMATIC HEART DISEASE

Authors

Turayev Telmon Temirovich,Bobojonov Khurshid Jumaniyozovich Bukhara State Medical Institute

Keywords:

chronic rheumatic heart disease, interleukin-10, TNF-alpha, cytokines, inflammation, children

Abstract

Chronic rheumatic heart disease (CRHD) remains a significant cause of acquired heart defects in children and adolescents. Immune dysregulation is central to disease progression. Cytokines, especially interleukin-10 (IL-10) and tumor necrosis factor-alpha (TNF-alpha), are key modulators of inflammation. This study investigates serum IL-10 and TNF-alpha levels as diagnostic and prognostic markers in pediatric CRHD.

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References

WHO. Rheumatic Fever and Rheumatic Heart Disease: Technical Report. Geneva, 2021.

Shabalov NP. Pediatrics: textbook. St. Petersburg: SpetsLit, 2020.

Ahmed A. et al. Cytokine imbalance in rheumatic heart disease. Clin Immunol Res. 2022;18(3):145-153.

Guidelines for Management of Rheumatic Fever and CRHD. Ministry of Health, 2020.

Braunwald E. Heart Disease: A Textbook of Cardiovascular Medicine. 12th ed., 2021.

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Published

2025-11-15

How to Cite

Turayev Telmon Temirovich,Bobojonov Khurshid Jumaniyozovich. (2025). THE ROLE OF INTERLEUKIN-10 AND TUMOR NECROSIS FACTOR-ALPHA IN CHRONIC RHEUMATIC HEART DISEASE. International Multidisciplinary Journal for Research & Development, 12(11), 248–249. Retrieved from https://ijmrd.in/index.php/imjrd/article/view/4020