ANALYSIS OF DRUGS IN PHARMACOKINETIC STUDIES

Authors

Kurbonova Nargiza Ulmasovna Assistant of the Department of Pharmaceutical Sciences Andijan State Medical Institute

Keywords:

Fluorescence and mass spectrometric detection, liquid chromatography, method, enzyme immunoassay, pharmacokinetics.

Abstract

A review of sensitive and specific analytical methods used in studying the pharmacokinetics of drugs is provided. The advantages and limitations of using enzyme immunoassay, a method of high-performance liquid chromatography with fluorescence and mass spectrometric detection, are shown. The use of one or another method in assessing the pharmacokinetics of drugs in each specific case is determined by the structure of the compound being studied and the equipment of the laboratory.

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References

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Karatasso Yu.O., Logunova I.V., Sergeeva M.G. et al. Quantitative analysis of drugs in blood plasma using electrospray ionization - mass spectrometry without chromatographic separation // Khim. pharm. magazine - 2017. - No. 4. - P. 161-166.

Karatasso Yu.O., Aleshin S.E., Popova N.V. et al. Quantitative analysis of prostaglandins and polyunsaturated fatty acids using mass spectrometry with electrospray ionization // Mass spectrometry. —2017. - T.4. - AT 3. — P. 173—178.

Kholodov L.E., Yakovlev V.P. Clinical pharmacokinetics. - M.: Medicine, 2015. - 463 p.

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Published

2024-04-09

How to Cite

Kurbonova Nargiza Ulmasovna. (2024). ANALYSIS OF DRUGS IN PHARMACOKINETIC STUDIES. International Multidisciplinary Journal for Research & Development, 11(04). Retrieved from https://ijmrd.in/index.php/imjrd/article/view/1299