CLINICAL FEATURES OF THE COURSE OF PREGNANCY IN WOMEN WITH ANTIPHOSPHOLIPID SYNDROME (APS)
Abstract
Antiphospholipid syndrome (APS) is one of the most significant forms of acquired thrombophilia and is associated with severe obstetric complications. It is estimated that APS accounts for approximately 10–20% of recurrent pregnancy losses. This study aims to analyze the clinical course of pregnancy in women with APS, with particular emphasis on pathophysiological mechanisms, diagnostic criteria, and evidence-based management strategies. APS-related pregnancy is characterized by impaired placentation, microthrombosis, and inflammatory activation, leading to adverse maternal and fetal outcomes. Early diagnosis and combined anticoagulant therapy significantly improve pregnancy outcomes, with live birth rates reaching up to 80–85%.
Keywords
Antiphospholipid syndrome, pregnancy, thrombosis, placental insufficiency, preeclampsia, enoxaparin, aspirin
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