CARDIOMYOCYTE FUNCTION AND MECHANISMS OF CARDIAC CONTRACTION: CLINICAL SIGNIFICANCE IN HEART FAILURE

Abstract

Cardiomyocytes play a central role in maintaining cardiac function through coordinated contraction and relaxation processes. The integrity of these cells and their electrophysiological and biochemical mechanisms determine the efficiency of cardiac output. Disruption in cardiomyocyte activity leads to impaired contractility, ultimately resulting in heart failure—a major global health problem. This article explores the anatomical and physiological basis of cardiomyocyte function, the molecular mechanisms underlying cardiac contraction, and the pathophysiological processes contributing to heart failure. The clinical implications of these mechanisms are also discussed to highlight their importance in diagnosis and treatment strategies.