CLINICAL AND HORMONAL MANIFESTATIONS OF HYPOTHALAMIC–PITUITARY DYSFUNCTION IN PRIMARY SCHOOL–AGED CHILDREN AFTER TRAUMATIC BRAIN INJURY

Authors

Khalimova Z.Yu., Inomova G.K. Andijan State Medical Institute, Department of Hospital Therapy and Endocrinology, Republican Specialized Scientific and Practical Medical Center of Endocrinology named after Academician Yo.Kh. Turakulov Uzbekistan, 170100, Andijan, 1 Yu. Atabekov Street

Keywords:

Traumatic brain injury, children, hypothalamic–pituitary dysfunction, neuroendocrine disorders, hormonal imbalance, pediatric endocrinology

Abstract

Traumatic brain injury (TBI) in children is a significant medical and social problem due to its potential long-term neurological and endocrine consequences. Among these, hypothalamic–pituitary dysfunction represents one of the most underdiagnosed but clinically important complications. This article analyzes the clinical and hormonal manifestations of hypothalamic–pituitary dysfunction in primary school–aged children following traumatic brain injury. The study highlights the spectrum of neuroendocrine disorders, their pathophysiological mechanisms, and diagnostic challenges. Understanding early clinical and hormonal changes is essential for timely diagnosis, appropriate management, and prevention of long-term complications in pediatric patients.

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References

Schneider, H. J., Kreitschmann-Andermahr, I., Ghigo, E., Stalla, G. K., & Agha, A. (2007). Hypothalamopituitary dysfunction following traumatic brain injury and aneurysmal subarachnoid hemorrhage. JAMA, 298(12), 1429–1438.

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Acerini, C. L., et al. (2013). Endocrine sequelae of traumatic brain injury in children. Archives of Disease in Childhood, 98(7), 567–572.

Kokshoorn, N. E., et al. (2010). Hypopituitarism following traumatic brain injury: Prevalence and clinical implications. Pituitary, 13(4), 273–279.

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Published

2026-01-19

How to Cite

Khalimova Z.Yu., Inomova G.K. (2026). CLINICAL AND HORMONAL MANIFESTATIONS OF HYPOTHALAMIC–PITUITARY DYSFUNCTION IN PRIMARY SCHOOL–AGED CHILDREN AFTER TRAUMATIC BRAIN INJURY. International Multidisciplinary Journal for Research & Development, 13(01), 567–569. Retrieved from https://ijmrd.in/index.php/imjrd/article/view/4810