THE NEUROBIOLOGY OF DEPRESSION AND NEW TREATMENT STRATEGIES: UNLOCKING THE MIND’S HIDDEN BATTLES

Authors

Tulayev Bobur Zoyir ugli , Pardayeva Azizabonu Ulug'bek qizi , Asadbek G'aniyev Ulug'bekovich, Eshmuradov Quyoshbek Sanjar ugli, Beknazarov Shahobiddin Fazliddin ugli Samarkand State Medical University

Keywords:

Depression, neurobiology, BDNF, HPA axis, neuroinflammation, ketamine, psilocybin, transcranial magnetic stimulation, treatment-resistant depression, mental health, brain plasticity, monoamine hypothesis, personalized psychiatry

Abstract

Depression is a leading cause of disability worldwide, affecting more than 280 million people. Traditionally considered a psychological disorder, recent advancements in neuroscience have revealed complex neurobiological underpinnings, including disruptions in neurotransmitter systems, neuroinflammation, and structural brain changes. This article explores the current understanding of the neurobiology of depression and evaluates innovative treatment strategies, such as ketamine, transcranial magnetic stimulation, and psilocybin-based therapy. By bridging classical approaches with novel discoveries, this review aims to shed light on the future direction of depression management.

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References

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Published

2025-06-13 — Updated on 2025-06-19

Versions

2025-06-19 (2)
2025-06-13 (1)

How to Cite

Tulayev Bobur Zoyir ugli , Pardayeva Azizabonu Ulug'bek qizi , Asadbek G'aniyev Ulug'bekovich, Eshmuradov Quyoshbek Sanjar ugli, Beknazarov Shahobiddin Fazliddin ugli. (2025). THE NEUROBIOLOGY OF DEPRESSION AND NEW TREATMENT STRATEGIES: UNLOCKING THE MIND’S HIDDEN BATTLES. International Multidisciplinary Journal for Research & Development, 12(06), 139–142. Retrieved from https://ijmrd.in/index.php/imjrd/article/view/3358 (Original work published June 13, 2025)